PictureBilly Hurst - AP
It was a questionable start for the Niners letting the Rams get a 14 point jump on them in the first quarter. 24 unanswered points and a pick six for rookie Dontae Johsnon sealed the win. Unfortunately for the 49ers, this win came at a cost. 

Patrick Willis left the game with a toe injury due to the turf and was seen later on the sidelines in a walking boot. More will be known once the team returns to the bay area. 

Jimmie Ward injured his quad. 

Mike Iupati left the game with a concussion. 

Stevie Johnson took a direct hit by a knee to his hip and left the game but per the 49ers twitter account, it isn't serious. 

The Niners are already without key players: Navorro Bowman, Aldon Smith, Anthony Davis and Tramaine Brock so the Next Man Up motto has already been in full effect. Expect to see much more from Dontae Johnson and Chris Borland this Sunday when the 49ers face the Denver Broncos.